When Ayano Aishi kills a person with any weapon, her uniform and weapon will be splattered with blood. Her sanity will decrease with each kill, although wearing the Tiny Thong Panties, belonging to the Occult Club, or increasing Ayano's Numbness level lowers the amount lost. To avoid getting arrested, Ayano must at least dispose of the uniform and the weapon using the incinerator. In future builds, different weapons may result in different amounts of blood, but this will be determined in the balance phase. One way to balance the weapons would be to make non-suspicious weapons less lethal with longer killing animations.
Currently, there are seventeen weapons Ayano can use. The only available weapons that can currently be seen on the Challenges Menu are the knife, box cutter, scissors, screwdriver, syringe, and katana.
Some weapons are considered non-suspicious and will not result in a reputation penalty if Ayano is seen carrying them. If Ayano is a member of a particular club, suspicious weapons associated with that club, such as the shovel as a member of the Gardening Club, will become non-suspicious.
Some weapons can be concealed, while others cannot. The player can check if a weapon is concealable by pressing the 1 key. As of the February 15th, 2016 Build, Ayano cannot use a non-concealable weapon when fighting a Heroic student, because the weapon is too unwieldy to use in close quarters and will result in automatically losing the struggle. Any non-concealable weapon can be hidden inside a cello case, a trash can, or a weapon case (exclusive to the Alphabet Killer challenge).
If Ayano drops a weapon 10 meters away from its initial location, it will be considered as suspicious. Students that find the weapon on the ground will report it to their teacher. The teacher will then pick it up and place it inside of a box in the Faculty Room. If the weapon is bloody, the teacher will call the police, and any other students that see the bloody weapon will run to their classrooms.
As of the December 1st, 2015 Build, the game will track whose blood and whose fingerprints are on each weapon. If Ayano does not dispose of a bloody weapon, a teacher will find it and call the police. The police will try to trace the weapon back to Ayano. If she wears gloves, the police will not find her fingerprints on the weapon. As a result of this, she is able to frame other students by using weapons they have touched to commit murder. This method can be used after Kokona Haruka uses the knife in the Cooking Club. Since Kokona's fingerprints are the only ones on the knife, she will be arrested for the murder.
In earlier builds, Ayano would automatically dropped all weapons when the day ended. This would have been troublesome for a player who forgot to dispose of a weapon would leave it on the ground when Ayano left school. A teacher would then find it and call the police, and the police could immediately trace the weapon to Ayano. As of the January 2nd, 2015 Build, she will instead take the weapon home and dispose of it. If the police arrive at school, however, they will search the students and find the bloody weapon on Ayano's body, so she will still be arrested.
- Main Article: Reputation
If students see Ayano carrying a dangerous weapon, they will see her as suspicious, thus damaging her reputation by ten points during high School Atmosphere, fifteen points during medium, and twenty points during low. Apologizing to a student will give her back some of the reputation lost. If a friend or a student that is being seduced by Ayano sees her with a weapon, her reputation will be affected by eight points. If she is in the Occult Club, it will take longer for students to notice her carrying a dangerous weapon.
If Senpai sees Ayano with a dangerous weapon, he will become terrified of her, resulting in a Game Over. If a teacher sees Ayano with a dangerous weapon, she will be sent to the Counselor's Office. If a teacher sees her holding a dangerous weapon after a student has been murdered, she will assume Ayano killed the student and pin her down, apprehending her.
The scissors, box cutter, and screwdriver are classified as non-suspicious weapons. Ayano will not be considered "Visibly Armed" when carrying these weapons. In the final game, the only weapons available will be ones found in a school environment, unless she asks Info-chan to leave a weapon at the back of the school.
If Ayano holds a suspicious (or bloody) weapon near the delinquents, they will assume a menacing stance, ready to fight. They will lower their guard after she puts it away, and taunt her. If the player walks up to the delinquents multiple times a battle minigame will activate. Winning this minigame will result in being able to take the delinquent's weapon and frame them for murder if the player wore gloves.The police can then trace the fingerprints on the weapon to the delinquents as long as Ayano did not leave her fingerprints on the weapon.
If multiple people have touched the weapon, the last person to touch the weapon would be framed, or Ayano would be arrested if she left her fingerprints on the weapon at any time. If many people are framed for many individual murders at once, the person "responsible" for the latest murder committed would be arrested only. This is due to programming limitations.
- Main Article: Sanity
- Stealth kill: Performed from behind, with victim unaware. Quick, quiet and clean.
Low sanity kill animations will last longer than high sanity ones.
- High sanity kill: Efficient, but not as fast as a stealth kill. Produces some extra noise and blood. Will take two seconds.
- Medium sanity kill: The victim struggles a little bit. The kill is sloppy and messy, thus taking more time. Will take four seconds.
- Low sanity kill: Very prolonged killing animation that is unnecessarily brutal and sadistic. Victim screams and struggles. The player has the option to make Ayano continue to stab her victim indefinitely by mashing the "attack" button, causing a segment of the animation to loop until the player stops mashing. Will take six seconds.
More animations could show additional kill techniques that vary depending on weapon type and current sanity level. Ideally, every weapon will eventually have an unique animation set. If this cannot happen, a less ideal scenario would be that each weapon type (short, stabbing, long, and bludgeoning) has its own animation set. At worst, all weapons will have the same animation.
- Main Article: Axe
Found outside the shed. Seen as suspicious and cannot be concealed. Ayano cannot fight back with it. She cannot pass it through a metal detector.
- Main Article: Baseball Bat
Found inside one of the storage rooms in the gym and can be dropped by Umeji Kizuguchi, a delinquent. Seen as suspicious, unless Ayano is in the Sports Club. Cannot be concealed. Ayano will have easy access to a bat in the Sports Club. She cannot fight back with it. She can pass it through a metal detector, since it is made of wood.
- Main Article: Boken
Can be dropped by Hokuto Furukizu. Seen as suspicious and cannot be concealed. Ayano cannot fight back with it. Can be passed through a metal detector, since it is made of wood.
- Main Article: Box Cutter
Found in the Art Club. Seen as non-suspicious and can be concealed. Can be used to frame students by putting it in a closed box that is found in the incinerator area, then asking students (cannot be Student Council members or delinquents) for assistance. Cannot be passed through a metal detector.
- Main Article: Circular Saw
Found inside the shed. Can also be used for dismemberment. Seen as suspicious and cannot be concealed. Ayano cannot fight back with it. Cannot be passed through a metal detector.
- Main Article: Crowbar
Can be dropped by Gaku Hikitsuri when winning the beat up minigame. Seen as suspicious and cannot be concealed. Ayano cannot fight back with it. Cannot be passed through the metal detector.
- Main Article: Dumbbell
Five of them can be found inside one of the storage rooms in the gym. Can be used to crush students or attack them. Seen as suspicious, unless Ayano is in the Sports Club. Cannot be concealed. Cannot be passed through a metal detector.
- Main Article: Energy Sword
This weapon is only found when Cyborg Mode is activated. Seen as suspicious and cannot be concealed. Ayano cannot fight back with it. It will spawn in front of the school gates. When used, it will dismember the student.
- Main Article: Fantasy Sword
Found inside the Drama Club. Seen as suspicious unless Ayano is in the Drama Club, and is non-concealable. Ayano cannot fight back with it.
- Main Article: Fire Extinguishers
They are found on all floors near the bathrooms. Ayano can wield it and hit students. Seen as suspicious and cannot be concealed.
- Main Article: Guitar
Found inside the Light Music Club. Seen as suspicious unless Ayano is part of the club. Ayano cannot fight back with it.
- Main Article: Katana
Found inside a case in the headmaster's office. Seen as suspicious and non-concealable. Ayano cannot fight back with it.
- Main Article: Knife
Found on the rooftop and inside the Cooking Club. Can be used to frame rivals. Usually seen as suspicious, but not if Ayano is standing inside the Cooking Club. It is concealable and cannot be passed through metal detectors.
- Main Article: Knife Blade
This weapon is only found when Yanketsu Mode is activated. Seen as suspicious and cannot be concealed. Ayano cannot fight back with it. It will spawn in front of the school gates. When used, it will dismember the targeted student.
Magical Girl Wand
- Main Article: Magical Girl Wand
Found inside the Drama Club. Seen as suspicious unless Ayano is in the Drama Club, and is non-concealable. Ayano cannot fight back with it. Ayano can use this weapon to activate the Magical Girl Pretty Miyuki easter egg.
- Main Article: Old Axe
Found behind the shed. Seen as suspicious and non-concealable. Ayano cannot fight back with it. Cannot be passed through a metal detector.
- Main Article: Pipe
Can be dropped by Hayanari Tsumeato. Seen as suspicious and cannot be concealed. Ayano cannot fight back with it. Cannot be passed through a metal detector.
- Main Article: Pipe Wrench
Found inside in the north-west school storage room on the First Floor. It can be used to sabotage the pipes of a drinking fountain. Seen as suspicious and cannot be concealed.
- Main Article: Ritual Knife
- Main Article: Scissors
Found in the sewing room. Seen as non-suspicious and can be concealed. Cannot pass through a metal detector.
- Main Article: Screwdriver
- Main Article: Shinai
Can be dropped by Dairoku Surikizu. Seen as suspicious and cannot be concealed. Ayano cannot fight back with it. Can pass through the metal detector, since it is made of wood.
- Main Article: Shovel
Found outside the shed. Seen as suspicious unless Ayano is in the Gardening Club and cannot be concealed. Can also be used to dig and fill up holes in the Gardening Club's garden to bury corpses. Ayano cannot fight back with it. Cannot pass through metal detectors.
- Main Article: Sword
Found inside the Drama Club. Seen as suspicious unless Ayano is in the Drama Club and is non-concealable. Ayano cannot fight back with it.
- Main Article: Syringe
Possibly Planned Weapons
Weapons that might be added in future builds:
- Butcher knife.
- Gardening sickle.
- Painting knife.
- Soda cans.
- Gardening shears.
- Glass Cutter.
Blunt weapons are planned and some models are already prepared.
There will be different types of weapons, like two-handed, swinging, stabbing, and strangling weapons.
|“||What do you want?! Don't hurt me! Stay away!||”|
— A student seeing a fully insane Ayano bloody and carrying a weapon.
— Delinquents after seeing Ayano hold a weapon.
|“||Don't even think about it!/I'll crack your skull open!/Looking for a fight, huh?!/You gotta death wish?!/Try it, I dare you!||”|
— Delinquents while watching Ayano hold a weapon.
|“||What are you doing, carrying something like that around? Have fun explaining this to the guidance counselor!||”|
— A teacher after catching Ayano holding a weapon.
|“||Just what do you think you're doing?!||”|
— A teacher resisting Ayano's attack with a weapon before pinning her to the ground.
|“||Why do you have a weapon? What are you going to do with that thing?! Stay back!||”|
— Senpai after seeing Ayano visibly armed.
|“||Yeah, that's what I thought. Coward./All talk and no action, huh./Hahahaha... I knew you didn't have the guts.||”|
— Delinquents after seeing Ayano put away a weapon.
- Non-conceal weapons (excluding katana, circular saw, baseball bat and swords from Drama Club) will count as "bloody weapon" if the player attack students with the front, even if the non-conceal weapons don't get bloody if the player attack students on the front.
- If the player wash weapon after getting bloody from killing someone, it will still count as "bloody weapon", lead to the police investigation.
- As of the October 15th, 2017 Build, sound effects for picking up weapons have been added.
- It is theoretically possible for a pencil to become a weapon, but YandereDev does not find it cool enough. He wants all weapons to be cool.
- There are more weapons available in the small town, but they are currently unprogrammed.
- YandereDev has stated in an interview that the katana might be something that Kocho Shuyona confiscated and just never got rid of.
- As of the November 15th, 2016 Build, the katana is located in the Headmaster's office.
- The headmaster was said to have never touched the katana since 1988.
- Ranged weapons will most likely not be in the game. This is likely to prevent the game from becoming too easy, as nobody has defense against any ranged weapon (like a helmet). For example, with a sniper rifle/crossbow or even a pistol (which is easily concealable), all what one needs to do is to shoot, hide, then dispose of the weapon. It can be said that even without a silenced weapon, it is extremely easy to win Senpai by killing all the rivals. The game is also a school environment, so most likely very few opponents will ever get to use a ranged weapon that definitely requires another to defeat.
- However, while the player cannot use any, there are NPCs with ranged weapons. The most obvious example is perhaps the headmaster who owns a Taser that causes great damage to anything living it zaps (he currently only attacks the player with it) and has a short range (longer than every other weapon).
- The police are a good candidate, though they are never seen with any ranged weapons, as most police officers will carry a pistol at the very least for security purposes.
- Formerly, there were only three regular animations with a murder weapon: a sideways stab to the neck for the knife, scissors, box cutter, screwdriver, syringe, and ritual knife, a slam to the head for the katana, baseball bat, shovel, dumbbell, and a unique animation for the circular saw. There is also a stab in the head whenever Ayano wins a fight against a Heroic student and another when brainwashed, kidnapped victims finish a murder-suicide. All of the weapon animations have been replaced with the sanity-based attacks, except during fights against a Heroic student.
- The animation used for the larger weapon, high sanity attack animations, (except the circular saw) is also used for when the old delinquents attack Ayano.
- Ayano intends to kill when the player presses the "attack" button. There is no chance of knocking the victim unconscious or leaving them "Half-dead".
- There is a possibility that a sniper mini-game will be added purely for fun. However, a sniper equivalent in the game is unlikely. With one, it will harm the gameplay experience since the weapon will likely sustain against several rivals before it risks discovery by Senpai.
- It is very important to YandereDev that there's a cheat code or Easter Egg which unlocks a giant sci-fi energy scythe.
- In the future, it is possible that if students see a certain weapon lying around, they will give it to a teacher.
- YandereDev does not have the animations nor the models for choking someone with a rope or a chain yet. 
- Cleaning bloody weapons can be done using a sink and the Drinking Fountains.
- YandereDev does not want to add ranged weapons to the game due to the sharp increase in school shootings in the United States in the past decade.